Life Sciences Construction for Labs, Cleanrooms and R&D Facilities
Rylko Builders delivers laboratory, cleanroom, and medical technology facilities throughout California and Arizona. From office-to-lab conversions and ISO 8 cleanrooms to complex R&D environments, we coordinate design-build MEP, construction, and certification to help life sciences companies bring innovative spaces online faster.
What Does Life Sciences Construction Involve?
Life sciences construction creates highly specialized environments for research, testing, medical technology development, and light manufacturing. Unlike traditional office construction, these facilities often require enhanced electrical capacity, specialized HVAC systems, process utilities such as compressed dry air (CDA), cleanroom environments, ESD protection, and regulatory compliance requirements. Successful projects depend on the careful coordination of building systems, equipment needs, and certification requirements from the earliest planning stages.
What We Build
- ISO 8 cleanrooms and controlled environments
- R&D laboratories with custom benching, power distribution, and utility drops
- Medical device and hardware testing laboratories, including MRI suites
- Office-to-lab conversions
- Market-ready laboratory suites for landlords and developers
- Headquarters that integrate laboratory and office space
- Biotech, pharmaceutical, and medtech research facilities
Preconstruction & Facility Evaluation
Before design begins, we assess the building's ability to support laboratory power demands, HVAC requirements, process utilities, and specialized equipment so clients can make informed real estate decisions.
Design-Build MEP Coordination
Working alongside our mechanical, electrical, plumbing, and process utility partners, we coordinate critical building systems early to reduce conflicts, improve constructability, and support efficient project delivery.
Construction, Certification & Turnover
We manage construction through final inspections, cleanroom testing, certification, and turnover documentation to help ensure a seamless move-in process.
Trusted by Life Sciences and Medical Technology Companies
Our life sciences experience includes projects for Cala Health, Intuitive Surgical, Natus Medical, Coherus BioSciences, Iovance Biotherapeutics, Geron, and other leading healthcare and medical technology organizations.
Highlighted Life Sciences Clients
- Cala Health
- Natus Medical
- PRA Health Sciences
- Octave
- Q-Bio
- Auris Health
- Coherus BioSciences
- Geron
- Iovance Biotherapeutics
- Intuitive Surgical
- LifeMax Laboratories
- Biocodex
- Mirum Pharmaceuticals
Frequently Asked Questions
What is an ISO 8 cleanroom?
An ISO 8 cleanroom is a controlled environment designed to limit airborne particles and contaminants. These spaces are commonly used for medical device assembly, testing, and research applications where cleanliness and environmental control are critical. Rylko Builders has delivered ISO 8 cleanroom projects for organizations including Cala Health and Q-Bio."
Can office space be converted to a lab?
Often, if the building can support the added power, HVAC and utility loads. Rylko converted office space to R&D labs for Cala Health in San Mateo, including cleanroom certification.
How long does a lab build-out take?
Most life sciences projects are completed within 8 to 24 weeks following permit issuance. Schedules vary based on project complexity, equipment procurement, utility upgrades, cleanroom certification requirements, and material lead times. During preconstruction, we identify these factors early to establish realistic timelines and reduce project risk.
What is a market-ready lab suite?
A spec suite built with lab infrastructure already in place, such as power, CDA and ESD flooring, so a tenant can move in faster.
Similar Projects
Planning a Lab or Cleanroom Project?
Whether you're evaluating a new facility, converting office space into a laboratory, or building an ISO 8 cleanroom, our team can help determine what your building can support before design begins.
Start Your Project | Call (415) 559-7251
Where We Work
Bay Area: San Mateo headquarters, serving San Francisco, the Peninsula, Oakland and San Jose.
Arizona: Life Sciences Construction as JKR Builders serving the Greater Phoenix Metro Area.
CA License 955155 | AZ ROC 366302 | Privately Owned | 16+ Years of Experience